Protection of Your Confidentiality
Hotel safes are not typically used to hold items of critical material value. The potentially catastrophic risks usually pertain to the risk of data breach. Easily infiltrated hotel safes illustrate the perils of insecure computing.
The most pernicious of catastrophic vulnerabilities for sophisticated targets pertain to surreptitious access to systems.
Any safe is hypothetically is portable, and cables and locks can be cut or drilled, but you will not be a victim to a potentially catastrophic invasion of your privacy via a surreptitious planting of surveillance technology.
Mere seconds of access to a smartphone or laptop can be sufficient to plant zero-day rootkit spyware, undetectable by security software and unstoppable by various other protections. Thereafter, these methods usually enable access to almost everything you type, what is displayed on your screen, almost all user data of any connected systems, entire phone calls (even if the infected device was a laptop, most people connect their cell phones—wirelessly synchronizing or charging by USB), and ambient sounds.
This particular situation presents an opportunity to use an adversary's own efforts against him. A sophisticated saboteur would see a hotel safe as an opportunity for exploitation, and would reasonably be confident in his or her ability to attempt to open it. Safes in ordinary hotel rooms are electronic for benefits to the hotel, with the same logic as an electronic room key. Yours, however, is different. With the electronic lock on your safe, you will know if someone improperly has attempted access. You would want to know if an adversary has infiltrated you to the point of attempting to breach your safe. The single instance of counterintelligence can provide you with multiple findings: awareness of your adversary's tracking methods, status, sophistication (methods used to open the safe), and determination.
From the legacy before biometrics and reinforced alloys, most embassies adopted the concept of burn safes. Now, you have the benefit of a safe that effectively provides the same mitigation, without the danger. Plasma cutters are effective on metal barriers, but the small air-tight compartment would bring internal temperatures far beyond the point of destroying the data of any hard drives and memory cards.